Publications by authors named "F Turner"
Background: The farnesoid X receptor (FXR) is a leading therapeutic target for metabolic dysfunction-associated steatohepatitis (MASH)-related fibrosis. INT-767, a potent FXR agonist, has shown promise in preclinical models. We aimed to define the mechanisms of INT-767 activity in experimental MASH and dissect cellular and molecular targets of FXR agonism in human disease.
View Article and Find Full Text PDFBackground: An increased body mass index (BMI) can lead to subfertility; however, current literature fails to exclude the effect of other confounding medical conditions, raising questions regarding the direct link between increased BMI and fertility outcomes.
Objectives: To conduct a systematic review and meta-analysis to elucidate the effects of increased BMI on fertility outcomes in females with no other comorbidities.
Search Strategy: A comprehensive search was conducted using EMBASE, MEDLINE and the Cochrane library from January 2000 until July 2023.
Article Synopsis
- Researchers studied how important it is to fully remove areas of the brain that cause seizures during surgery for patients who can't control their epilepsy with medicine.
- They looked at data from 63 patients and found that most had a lot of the problem areas taken out, but it didn't seem to help them avoid seizures afterward.
- The study concluded that just removing the seizure areas isn't enough to guarantee no more seizures, suggesting that there might be other reasons for seizures after surgery.
Article Synopsis
- * A 55-year-old man with a malfunctioning gastrojejunostomy tube came to the ER with mental status changes and was diagnosed with metabolic alkalosis and related issues.
- * The patient recovered after electrolyte replenishment and replacing the faulty tube, emphasizing the significance of understanding acid-base balance in gastrointestinal health.
Dyadic Developmental Psychotherapy (DDP) is a family-based therapy for adopted children aiming to achieve secure attachment between the child and parent. Due to restrictions under the COVID-19 pandemic, delivery of DDP transitioned from face-to-face to online methods. This study aimed to explore families experience of online DDP compared to face-to-face DDP, looking at the advantages and disadvantages of remote delivery methods and the implications this has on future service delivery for clinicians.
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