The effects of nutritional supplementation for children and adolescents with sickle cell disease: A systematic review and meta-analyses.

Background & Aims: Sickle cell disease (SCD), a neglected chronic genetic blood disorder that severely impacts the pediatric population, often leading to premature death, is associated with compromised nutritional status. This study aimed to evaluate the effect of nutritional supplementation in SCD-related complications.

Methods: A systematic review with searches in PubMed, Scopus and Web of Science was performed.

Accuracy of diagnostic tests for feline sporotrichosis: A systematic review and meta-analysis.

Background: Feline sporotrichosis is a subcutaneous infection caused by fungi of the Sporothrix genus, particularly concerning in endemic regions of South America, where cats are important vectors. Traditional diagnosis through fungal culture is time-consuming, which can delay the start of treatment.

Objective: Our goal was to synthesize the evidence on the accuracy of alternative diagnostic methods for feline sporotrichosis.

Addressing Challenges to Enhance Clinical Research in Portugal: Insights from the OncoT3 Expert Group Delphi Study.

Introduction Over the past decades, clinical research has evolved significantly, driven by advances in regulatory frameworks, technological innovations, and methodological approaches. In Portugal, while there has been progress - such as increased regulatory alignment with European standards and the adoption of digital trial management tools - various challenges remain. These may include, among others, limited access to funding, slower patient recruitment rates, and regulatory hurdles that can delay trial approvals.