Polybrominated diphenyl ethers isolated from the marine sponge collected in Mayotte.

CDK7 and FynB protein kinases have been recognized as relevant targets for cancer and brain diseases treatment due to their pivotal regulatory roles in cellular functions such as cell cycle and neural signal transduction. Several studies demonstrated that the inhibition of these proteins could be useful in altering the onset or progression of these diseases. Based on bioassay-guided approach, the extract of the marine sponge (Thorectidae), which exhibited interesting kinase inhibitory activities, was fractionated.

An Aminopyrimidone and Aminoimidazoles Alkaloids from the Rodrigues Calcareous Marine Sponge .

A chemical study of the CHCl-MeOH (1:1) extract from the sponge collected in Rodrigues (Mauritius) based on a molecular networking dereplication strategy highlighted one novel aminopyrimidone alkaloid compound, ernstine A (), seven new aminoimidazole alkaloid compounds, phorbatopsins D-E (, ), calcaridine C (), naamines H-I (, ), naamidines J-K (, ), along with the known thymidine (). Their structures were established by spectroscopic analysis (1D and 2D NMR spectra and HRESIMS data). To improve the investigation of this unstudied calcareous marine sponge, a metabolomic study by molecular networking was conducted.

Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge sp.

Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge sp. collected in Mayotte highlighted three new long-chain highly oxygenated polyacetylenes, osirisynes G-I (-) together with the known osirisynes A (), B (), and E (). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS and MS/MS data.

Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge n. sp.

Four new brominated tyrosine metabolites, aplyzanzines C-F (-), were isolated from the French Polynesian sponge n. sp., along with the two known 2-aminoimidazolic derivatives, purealidin A () and previously isolated, respectively, from the sponges and Verongula sp.

Quorum sensing inhibitors from Leucetta chagosensis Dendy, 1863.

Unlabelled: Sponges are a rich source for investigation of bioactive small molecules. They have been mostly investigated for the search of new pharmacological models or therapeutic agents for the treatment of human diseases. Micro-organisms can also represent a virulent pathogen for marine invertebrates such as sponges, which need to protect themselves against these microbes.