Publications by authors named "F Terzi"
Article Synopsis
- Doctors can now use special molecules in urine called CXCL9 and CXCL10 to check how well kidney transplants are doing and if there's a risk of rejection.
- A new test for measuring these molecules is fast and easy to use, giving results in just 90 minutes.
- This test is super accurate and could help doctors make better decisions about patient care in kidney transplants.
Background: The lysosomal autophagic pathway plays a fundamental role in cellular and tissue homeostasis, and its deregulation is linked to human pathologies including kidney diseases. Autophagy can randomly degrade cytoplasmic components in a nonselective manner commonly referred to as bulk autophagy. In contrast, selective forms of autophagy specifically target cytoplasmic structures such as organelles and protein aggregates, thereby being important for cellular quality control and organelle homeostasis.
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- GSDIa leads to metabolic changes in kidney cells, resembling Warburg-like metabolism, which promotes cell growth and the development of kidney cysts.
- The loss of glucose-6 phosphatase (G6PC1) causes harmful accumulation of glycogen and lipids, leading to kidney inflammation, fibrosis, and dysfunction.
- Treatment with rapamycin showed potential in reducing kidney damage, and lipocalin 2 was identified as an important factor in kidney inflammation and early CKD progression.
Proliferative glomerulonephritis is a severe condition that often leads to kidney failure. There is a significant lack of effective treatment for these disorders. Here, following the identification of a somatic PIK3CA gain-of-function mutation in podocytes of a patient, we demonstrate using multiple genetically engineered mouse models, single-cell RNA sequencing, and spatial transcriptomics the crucial role played by this pathway for proliferative glomerulonephritis development by promoting podocyte proliferation, dedifferentiation, and inflammation.
View Article and Find Full Text PDFBackground: Hemorrhagic shock (HS) and rhabdomyolysis (RM) are two important risk factors for acute kidney injury after severe trauma; however, the effects of the combination of RM and HS on kidney function are unknown. The purpose of this study was to determine the impact of RM and HS on renal function, oxygenation, perfusion, and morphology in a pig model.
Methods: Forty-seven female pigs were divided into five groups: sham, RM, HS, HS and moderate RM (RM4/HS), and HS and severe RM (RM8/HS).