Publications by authors named "F Tenenbaum"
Purpose Of The Report: Adrenocortical carcinoma (ACC) is an extremely rare endocrine malignancy, which cannot always be diagnosed during conventional radiology and hormonal investigations. 18 F-FDG PET could help predict malignancy, but more data are necessary to support future guidelines.
Methods: A cohort of 63 patients with histologically proven ACC (n = 55) or metastatic ACC with steroid oversecretion (n = 8) was assembled.
Article Synopsis
- - The detection and characterization of adrenal lesions have improved significantly over the past 20 years, with imaging techniques like CT being central for diagnosis, especially for hormone-secreting lesions.
- - Non-functioning adrenal lesions pose a challenge for accurate diagnosis, often requiring a combination of imaging methods to determine which lesions necessitate surgery or biopsy.
- - New advancements such as dual-energy CT, MRI, and F-FDG PET/CT are enhancing the ability to differentiate between benign and malignant lesions, while emerging technologies like radiomics and artificial intelligence offer promising results in improving diagnostic accuracy.
We report the case of a 75-year-old woman with liver metastasis as a recurrence of a pheochromocytoma resected 10 years ago, with a rare germline mutation in transmembrane protein 127, falsely negative on 18F-FDOPA and 18F-FDG PET/CT scans but strongly positive on 123I-MIBG scintigraphy and on 68Ga-DOTATOC PET/CT. Functional imaging has a key role in diagnosis of pheochromocytoma and paraganglioma, especially 18F-FDOPA shows very high sensitivity and specificity. However, 18F-FDOPA might be falsely negative in some of these tumors, depending on specific mutations, and thus MIBG or 68Ga-DOTATOC imaging could be an alternative.
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