Publications by authors named "F Tatzber"
One of the most prominent actions of oxidative stress is the attack of free radicals on poylyunsaturated fatty acids (PUFAs), initiating a chain reaction to modify these PUFAs and generate oxidized modifications on all biomolecules. In the last quarter of the 20th century, intensive research was carried out to identify antibodies against such modifications. In the mid-1990s, the first enzyme-linked immunosorbent assay (ELISA) was introduced to the market, significantly accelerating research activities and knowledge gain.
View Article and Find Full Text PDFThere is little doubt that final victories over pandemics, such as COVID-19, are attributed to herd immunity, either through post-disease convalescence or active immunization of a high percentage of the world's population with vaccines, which demonstrate protection from infection and transmission and are available in large quantities at reasonable prices. However, it is assumable that humans with immune defects or immune suppression, e.g.
View Article and Find Full Text PDFThorough understanding of metabolic changes, including lipidome alteration, associated with the development of COVID-19 appears to be crucial, as new types of coronaviruses are still reported. In this study, we analyzed the differences in the plasma phospholipid profiles of the deceased COVID-19 patients, those who recovered and healthy people. Due to identified abnormalities in plasma phospholipid profiles, deceased patients were further divided into two subgroups (D1 and D2).
View Article and Find Full Text PDFArticle Synopsis
- Physical workload significantly increases inflammation, oxidative stress, and psychological stress in metalworkers compared to office workers, despite having adequate antioxidant levels.
- The study analyzed blood samples for various parameters, revealing sex-specific differences in factors like DHEAS and testosterone, and showed that older workers may face hormonal changes that heighten health risks.
- The results suggest that heavy labor leads to higher oxidative and psychological stress, while sedentary office work can lead to lifestyle-related diseases due to differing occupational habits.
Background: Little is known about the effects of hypoxia on scavenger receptors (SRs) levels in adipocytes. We analyzed the effect of morbid obesity and hypoxia on SRs and inflammation markers in human visceral adipocytes and whether ox-LDL modify the inflammatory profile produced by hypoxia.
Methods: We studied in 17 non-obese and 20 subjects with morbid obesity (MO) the mRNA expression of HIF-1α, SRs (LOX-1, MSR1, CL-P1 and CXCL16), IL6 and TNFα in visceral adipocytes and the effect of hypoxia with or without ox-LDL on visceral in vitro-differentiated adipocytes (VDA).