Publications by authors named "F T Amaral"
Microglia are crucial for brain development and their function can be impacted by postnatal insults, such as early-life allergies. These are characterized by an upregulation of interleukin (IL)-4 levels. Allergies share a strong comorbidity with Autism Spectrum Disorders (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD).
View Article and Find Full Text PDFDisruption of survivin protein expression by treatment with YM155 accelerates the resolution of neutrophilic inflammation.
Br J Pharmacol
November 2024
Background And Purpose: Prolonged survival of neutrophils is essential for determining the progression and severity of inflammatory and immune-mediated disorders, including gouty arthritis. Survivin, an anti-apoptotic molecule, has been described as a regulator of cell survival. This study aims to examine the effects of YM155 treatment, a survivin selective suppressant, in maintaining neutrophil survival in vitro and in vivo experimental settings of neutrophilic inflammation.
View Article and Find Full Text PDFArticle Synopsis
- Equine piroplasmosis, a disease caused by Babesia and Theileria parasites transmitted by ticks, poses significant clinical and economic threats globally, particularly to horses.
- This research focused on analyzing the heat shock protein 70 kDa (hsp70) gene sequences of Theileria equi from infected horses in Brazil, using methods like PCR and phylogenetic analysis to explore genetic relationships among parasites.
- Findings revealed two distinct genotypes of T. equi in Brazil, with hsp70 proving to be an effective molecular marker for distinguishing between closely related species and offering insights into the evolutionary history of these parasites.
Ethnopharmacological Relevance: Echinodorus macrophyllus is a medicinal plant traditionally used in Brazil to treat rheumatic diseases. It is listed as a priority species for the development of herbal preparations for the Brazilian Unified Health System (SUS). Previous studies have demonstrated the anti-inflammatory and antiedematogenic properties of extracts and fractions from this species, but these preparations were neither standardized nor optimized for anti-arthritis effects.
View Article and Find Full Text PDFBackground: Following the conclusion of a stepped-wedge cluster randomized trial of the Systems Analysis and Improvement Approach (SAIA) to optimize the prevention of mother-to-child HIV transmission cascade in Manica Province, Mozambique, we conducted a natural experiment to test the sustainability of the delivery model with limited financial inputs.
Methods: District nurse supervisors were encouraged to continue to facilitate SAIA cycles in subordinate health facilities and provided phone credit and tablet access to upload implementation data. No additional resources (eg, funds for transport, refreshments, or supplies) were provided.