Publications by authors named "F Sugihara"
Article Synopsis
- Circular RNAs (circRNAs) are unique RNA molecules that resist degradation, offering potential as stable biomarkers and therapeutic targets for diseases.
- This study focused on analyzing circRNAs during the response to the BNT162b2 mRNA vaccine by sequencing blood samples from healthcare workers.
- A total of 4706 circRNAs were identified, with 4217 being newly expressed during vaccination, suggesting they play a role in immune response and are associated with stress granule assemblies and specific RNA binding proteins.
Whereas severe COVID-19 is often associated with elevated autoantibody titers, the underlying mechanism behind their generation has remained unclear. Here we report clonal composition and diversity of autoantibodies in humoral response to SARS-CoV-2. Immunoglobulin repertoire analysis and characterization of plasmablast-derived monoclonal antibodies uncovered clonal expansion of plasmablasts producing cardiolipin (CL)-reactive autoantibodies.
View Article and Find Full Text PDFResting memory B cells can be divided into classical or atypical groups, but the heterogenous marker expression on activated memory B cells makes similar classification difficult. Here, by longitudinal analysis of mass cytometry and CITE-seq data from cohorts with COVID-19, bacterial sepsis, or BNT162b2 mRNA vaccine, we observe that resting B cell memory consist of classical CD45RB memory and CD45RB memory, of which the latter contains of two distinct groups of CD11c atypical and CD23 non-classical memory cells. CD45RB levels remain stable in these cells after activation, thereby enabling the tracking of activated B cells and plasmablasts derived from either CD45RB or CD45RB memory B cells.
View Article and Find Full Text PDFArticle Synopsis
- - This study aimed to compare the safety and effectiveness of two embolization methods (nBCA-ethiodized oil [NE] and nBCA-ethiodized oil-ethanol [NEE]) for treating Type II endoleak (T2EL) after endovascular aortic repair, involving 24 patients across 49 procedures.
- - Follow-up revealed that while both methods had no serious adverse events, the NEE group had better outcomes, showing 87.5% freedom from sac enlargement and 100% freedom from reintervention at 1 year, compared to 65.0% and 69.2% in the NE group, respectively.
- - The findings suggest that the N
Article Synopsis
- The study investigates whether preemptive embolization of side branch arteries from the abdominal aortic aneurysm sac can lead to early shrinkage of the aneurysm after endovascular repair.
- Results showed that the embolization group had a significantly higher occlusion rate of side branch arteries and a lower frequency of type 2 endoleaks compared to the nonembolization group over a 24-month follow-up.
- Additionally, patients in the embolization group were more likely to experience a reduction in aneurysm sac diameter of over 5 mm, suggesting that preemptive embolization may be beneficial for aneurysm treatment.