Cellular and molecular aspects of drug resistance in cancers.

Objectives: Cancer drug resistance is a multifaceted phenomenon. The present review article aims to comprehensively analyze the cellular and molecular aspects of drug resistance in cancer and the strategies employed to overcome it.

Evidence Acquisition: A systematic search of relevant literature was conducted using electronic databases such as PubMed, Scopus, and Web of Science using appropriate key words.

Fractional boundary element solution of three-temperature thermoelectric problems.

The primary goal of this article is to propose a new fractional boundary element technique for solving nonlinear three-temperature (3 T) thermoelectric problems. Analytical solution of the current problem is extremely difficult to obtain. To overcome this difficulty, a new numerical technique must be developed to solve such problem.

COVID-19-associated leukocytoclastic vasculitis leading to gangrene and amputation.

A 41-year-old male with type 2 diabetes mellitus (T2DM) presented with complaints of recent onset limb weakness, diffuse body rash and fever. Computerized Tomography (CT) scan of the brain did not reveal a stroke but laboratory investigations of the patient portrayed multi-systemic involvement. Naso-pharyngeal swab for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was taken which resulted as positive.

Sarcoidosis in the eastern region of Saudi Arabia.

Aim: To review a general hospital's experience with sarcoidosis and the clinical pattern of the disease among Saudis.

Methods: A retrospective file review was carried out on all patients with a proven diagnosis of sarcoidosis in a general hospital in Eastern Saudi Arabia over a period of 11 years (1998-2008).

Results: Sixty-nine patients, of whom 33 cases were included in the analyses, were diagnosed to have sarcoidosis during the study period.