Publications by authors named "F Strutz"
Background: Chronic renal insufficiency (CRI) is becoming more common and has an increasing impact on public health. In Germany, approximately one in ten adults has CRI. Its most serious consequence is generally not the development of end-stage renal failure, but rather the markedly increased cardiovascular risk as kidney function declines.
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- Daprodustat is being tested as an oral alternative to traditional ESAs for treating anemia in patients with chronic kidney disease starting dialysis, with limited past studies on this topic.
- The clinical trial involved a randomized, open-label design across 90 centers in 14 countries, focusing on patients who were either set to begin dialysis soon or had started within the last 90 days.
- The main goal was to compare the effectiveness and safety of daprodustat to darbepoetin alfa by assessing changes in hemoglobin levels and monitoring adverse events over a treatment period of 28 to 52 weeks.
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenetic kidney disease. The clinical course is highly variable, association to certain genetic mutations only weak. Great progress has been made in recent years in determining the pathophysiology of the disease.
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