Allopregnanolone in the Pathogenesis of the Psychiatric Comorbidities of Polycystic Ovarian Syndrome.

Context: Polycystic ovarian syndrome (PCOS) is an endocrine disorder affecting 10-15% of women of reproductive age, with significant implications for both physical and mental health. Several recent research studies have examined the connection between PCOS and psychiatric disorders; however, the mechanism linking the two is not fully understood. Allopregnanolone is a neurosteroid that modulates GABA receptors and is naturally affected by the pathophysiology of PCOS.

Sex steroid hormones and subclinical atherosclerosis progression in postmenopausal women.

Objective: The Early versus Late Intervention Trial with Estradiol demonstrated that hormone therapy (HT) reduces subclinical atherosclerosis progression in healthy postmenopausal women who initiated HT in proximity to menopause (<6 years) but not in those distant from menopause (≥10 years). This analysis explores the role of serum sex steroid hormones and sex hormone-binding globulin (SHBG) in atherosclerosis progression, examining differences based on time since menopause.

Design: Post-trial analysis.

Sublingual progesterone lozenges are a viable alternative to intramuscular progesterone-in-oil for programmed frozen embryo transfer cycles.

Objective: To compare pregnancy outcomes and serum progesterone levels between women who took sublingual (SL) progesterone lozenges vs. intramuscular (IM) administration progesterone-in-oil for endometrial preparation and luteal support in programmed frozen embryo transfer (pFET) cycles.

Design: Retrospective cohort study.