Publications by authors named "F Spyropoulos"
The role of stress granules (SGs) in pulmonary arterial hypertension (PAH) is unknown. We hypothesized that SG formation contributes to abnormal vascular phenotypes, and cardiac and skeletal muscle dysfunction in PAH. Using the rat Sugen/hypoxia (SU/Hx) model of PAH, we demonstrate the formation of SG puncta and increased expression of SG proteins compared to control animals in lungs, right ventricles, and soleus muscles.
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- Co-delivery strategies using Pickering emulsions, specifically solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), are being explored to improve the regulation of active ingredients' release profiles.
- The study investigates how different lipid and surfactant formulations impact the release rates of hydrophobic actives encapsulated both in the lipid particles and in the emulsion droplets, revealing that lipid compatibility and surfactant presence significantly influence release control.
- Despite variations in formulation, all tested particles managed to regulate active release from emulsion droplets, and co-release of two actives maintained consistent performance over a month, showing resilience through storage.
The patent ductus arteriosus (PDA) is associated with significant morbidity and mortality in preterm infants. While pharmacologic closure of the PDA is common and effective, it can be difficult to identify which patients will respond. As such, the objective of this study was to identify factors associated with successful pharmacologic closure of the PDA.
View Article and Find Full Text PDFThe typically low solubility and gelation capacity of plant proteins can impose challenges in the design of high-quality plant-based foods. The acid used during the precipitation step of plant protein isolate extraction can influence protein functionality. Here, acetic acid and citric acid were used to extract quinoa protein isolate (QPI) from quinoa flour, as these acids are more kosmotropic than the commonly used HCl, promoting the stabilisation of the native protein structure.
View Article and Find Full Text PDFThe chaperone protein EROS ("Essential for Reactive Oxygen Species") was recently discovered in phagocytes. EROS was shown to regulate the abundance of the ROS-producing enzyme NADPH oxidase isoform 2 (NOX2) and to control ROS-mediated cell killing. Reactive oxygen species are important not only in immune surveillance, but also modulate physiological signaling responses in multiple tissues.
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