Publications by authors named "F Springer"
The number of people living with or after cancer is steadily increasing due to an ageing society and improved cancer treatment. However, once treatment has been completed, the consequences of the disease are often felt for a long time. These affect many different areas of life and often lead to a high level of suffering and need for care.
View Article and Find Full Text PDFArticle Synopsis
- Drug toxicity, particularly from non-steroidal anti-inflammatory drugs like diclofenac, contributes to chronic liver damage and disrupts bone health by affecting the liver-bone axis.
- Researchers developed a reliable in vitro liver-bone co-culture model to study the effects of diclofenac on bone and liver interactions, finding optimal culture conditions for both systems.
- The study revealed that chronic exposure to diclofenac enhances osteoclast-like cell activity in the co-culture, leading to reduced mineral content and stiffness in bone scaffolds, driven by oxidative stress and inflammation rather than diclofenac’s main metabolic products.
Background: Older patients with cancer already represent the largest proportion of cancer survivors which will further increase in the upcoming years. However, older patients are highly underrepresented in clinical research, leading to a detrimental knowledge gap. Research on important aspects of quality of life (QoL) and associated factors for older patients with cancer is insufficient to date.
View Article and Find Full Text PDFArticle Synopsis
- The treatment for poisoning from certain harmful chemicals, like nerve agents, is still hard to find because current medicines don't work very well.
- These toxic chemicals affect a crucial enzyme that helps our nerves communicate, which can lead to serious health problems and even death if not treated properly.
- Researchers are working on new tests to discover better medicines that can target specific parts of these toxins, using a special method that makes the testing process easier and faster.
Objectives: The extent of health-related quality of life (HRQOL) impairments in older hematological cancer survivors (HCS) has not been sufficiently studied. We therefore examined HRQOL in older HCS compared to a community sample (CS) and investigated sociodemographic, disease- and treatment-specific, geriatric, and psychosocial factors associated with reduced HRQOL.
Materials And Methods: In this cancer-register-based cross-sectional comparative study 200 HCS, aged ≥70 years, and 252 persons of an age- and gender-matched CS completed validated questionnaires including the EORTC QLQ-C30 and EORTC QLQ-ELD14.