Publications by authors named "F Skorpen"
Background: Opioids in step III of the WHO analgesic ladder are the standard of care for treating cancer pain. However, a significant minority of patients do not benefit from therapy. Genetics might play a role in predisposing patients to a good or poor response to opioids.
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- Opioids are commonly used to manage cancer pain, but 10%-20% of patients either do not respond well or suffer from negative side effects, potentially due to genetic differences.
- A genome-wide association study (GWAS) was conducted on cancer patients across Europe to find genetic markers related to opioid-induced nausea and vomiting.
- The study identified 65 genetic variants linked to nausea-vomiting scores, including variants in the NPAS2 gene, paving the way for more personalized cancer pain management strategies through further research.
Article Synopsis
- Current prognostic tools for colorectal cancer (CRC) are inadequate, making it essential to find better methods for personalized treatment.* -
- This study investigated the role of circulating tumor DNA (ctDNA) biomarkers in predicting patient outcomes, analyzing samples from CRC patients diagnosed within 24 months.* -
- Results showed that certain methylated ctDNA markers, particularly RARB, SDC2, and WNT5A, independently predicted overall survival, recurrence-free survival, and poor prognosis, suggesting their potential use in personalized treatment strategies.*
Background: Colorectal cancer (CRC) is often diagnosed in advanced stages. Circulating tumour DNA (ctDNA) has been proposed as an early diagnostic biomarker. However, as a screening tool, ctDNA has mainly been studied in selected populations at the time of clinical diagnosis.
View Article and Find Full Text PDFBackground: It is unclear if smoking-related DNA methylation represents a causal pathway between smoking and risk of lung cancer. We sought to identify novel smoking-related DNA methylation sites in blood, with repeated measurements, and to appraise the putative role of DNA methylation in the pathway between smoking and lung cancer development.
Methods: We derived a nested case-control study from the Trøndelag Health Study (HUNT), including 140 incident patients who developed lung cancer during 2009-13 and 140 controls.