Publications by authors named "F Simona"
Background: An increasing amount of evidence suggests that migraine is a response to cerebral energy deficiencies or oxidative stress levels that exceed antioxidant capacity. Current pharmacological options are inadequate in treating patients with chronic migraine, and a growing interest focuses on nutritional approaches as non-pharmacological treatments. The ketogenic diet, mimicking fasting that leads to an elevation of ketone bodies, is a therapeutic intervention targeting cerebral metabolism that has recently shown great promise in the prevention of migraines.
View Article and Find Full Text PDFAcute kidney injury (AKI) manifests as a major health concern, particularly for the elderly. Understanding AKI-related proteome changes is critical for prevention and development of novel therapeutics to recover kidney function and to mitigate the susceptibility for recurrent AKI or development of chronic kidney disease. In this study, mouse kidneys were subjected to ischemia-reperfusion injury, and the contralateral kidneys remained uninjured to enable comparison and assess injury-induced changes in the kidney proteome.
View Article and Find Full Text PDFArticle Synopsis
- Acute kidney injury (AKI) is a significant health issue, especially in elderly populations, and research into its proteome changes is vital for new treatments.
- The study analyzed mouse kidneys affected by ischemia-reperfusion injury using advanced mass spectrometry for in-depth protein identification and quantification.
- Results showed that over half of the proteins in the injured kidneys changed significantly, with a notable decline in proteins related to energy production, pointing to a complete remodeling of the kidney proteome in response to AKI.
Lurbinectedin improves macular edema in a case of central retinal vein occlusion.
Am J Ophthalmol Case Rep
December 2022
Purpose: To evaluate the response to lurbinectedin in a case of macular edema, secondary to central retinal vein occlusion (CRVO). Serial spectral domain optical coherence tomography (SD-OCT) scans were taken in a 70-year-old man with a 24-month history of macular edema secondary to CRVO in the right eye. The patient underwent 5 cycles of chemotherapy with lurbinectedin between October 2018 and May 2019.
View Article and Find Full Text PDFIntroduction: Published data on possible ocular adverse events potentially associated with vaccination with the SARS-Cov-2 mRNA-1237 vaccine are scarce. In this report, we describe the case of a patient who had a hemispheric retinal vein occlusion potentially associated with being vaccinated with the second dose of the SARS-Cov-2 mRNA-1237 vaccine.
Methods: Case report including a discussion on multimodal imaging.