Publications by authors named "F Short"
Antimicrobial resistance (AMR) has been declared one of the top 10 global public health challenges of our age by the World Health Organization, and the World Bank describes AMR as a crisis affecting the finance, health, and agriculture sectors and a major threat to the attainment of Sustainable Development Goals. But what is AMR? It is a phenotype that evolves in microbes exposed to antimicrobial molecules and causes dangerous infections. This suggests that scientists and healthcare workers should be on the frontline in the search for sustainable solutions to AMR.
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- The study isolated two sub-populations of the bacteriophage Merri-merri-uth nyilam marra-natj (phage MMNM) in a Wurundjeri waterway, revealing minor phenotypic differences between them, particularly in their infection abilities.
- Through experimental evolution, 20 distinct phages were developed and sequenced, showing mutations concentrated in proteins that form the baseplate of the phage, similar to other minimalist phages.
- The research highlights that small mutations can drive phenotypic variation in phages, suggesting an alternative evolutionary pathway to the well-understood method of phage mosaicism for increasing host range diversity.
Article Synopsis
- Pathogenic and antimicrobial-resistant (AMR) germs are spread between humans, animals, and the environment, making diseases harder to treat.
- We need better ways to track these germs by combining efforts from different fields instead of working separately.
- The text suggests improving detection methods and creating strong systems to share information about these germs, helping everyone stay healthier.
is consistently ranked among the most problematic multidrug-resistant bacterial pathogens in healthcare systems. Developing novel treatments requires a better understanding of its interaction with the host environment. Although bacteria can synthesize fatty acids, emerging findings suggest a potential preference for their acquisition from the host.
View Article and Find Full Text PDFDPANN is a widespread and diverse group of archaea characterized by their small size, reduced genome, limited metabolic pathways, and symbiotic existence. Known DPANN species are predominantly obligate ectosymbionts that depend on their host for proliferation. The structural and molecular details of host recognition, host-DPANN intercellular communication, and host adaptation in response to DPANN attachment remain unknown.
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