[Morphologic features of the liver changes in rats of both gender exposed to aerogenic toxicants for a long period of time].

The liver affected by different toxicants in most cases responds in a similar way histomorphologically known as microcirculation disorder, the development of inflammatory area infiltrated with mononuclear cells, prime elements structure disorder, destructive-dystrophic changes of hepatocytes, which in some cases turn out necrotic. The character and degree of the hepatic response depends on a chemical component, exposition time and gender. Phenol and formaldehyde caused the most considerable alterations in the rats' livers, whereas the rats subjected to ammonin and sulfur dioxide intoxication had the least alterations in their livers.

[Lipid peroxidation and enzymes of the antioxidant defense system in patients with bronchial asthma].

In 71 patient with bronchial asthma (BA), lipid peroxidation (LPO) was studied together with the condition of the antioxidant system (AOS) as related to the degree of severity of the illness, with results evaluated of conventional therapy versus complex treatment involving the use of cytochrome C. Established in the above series was intensification of LPO in the presence of inhibition of activity of SOD enzymes and catalase, their degree dependent on severity of the condition. Unlike basic therapy, employment of cytochrome C has been found to be associated with a more complete restoration of balance in the LPO/AOS system, especially so in steroid-independent form of BA.

[Sex factors in effects of aerogenic toxic substances on the duration of hexenal-induced sleep].

Inhalant poisoning with low doses of toxicants during 3 months resulted in slowing the biotransformation of hexenal in male rats, whereas lead acetate and sulphur dioxide were less active. Unlike the male rats, phenol in female ones prolonged hexenal-induced dream. Ammonia did not effect the biotransformation, whereas formaldehyde, lead acetate and sulphur dioxide accelerated it.

[Morphological peculiarities of rat liver reaction to chronic xenobiotic exposure].

The data of the morphological studies of liver of animals subjected to chronic (3 months long) intoxication with different chemical substances (ammonium nitrogen, nitrite nitrogen, fluorine, chromium, arsenic) are presented. The xenobiotics tested induced stereotyped responses in liver which differed in their intensity and the extent of hemomicrocirculatory and inflammatory-destructive alterations. Most pronounced reactive changes were found in animals exposed to arsenic compounds, while sodium nitrate caused practically no destructive changes in hepatocytes.

[Effects of kavergal on indices of lipid peroxidation and the condition of the antioxidant system in patients with rheumatic heart disease presenting with circulatory insufficiency].

132 patients with rheumatic heart disease presenting with circulatory insufficiency displayed increased LPO both in the blood plasma and red cells, decline in the antioxidant enzymes activity varying with the circulatory insufficiency functional class degree of severity. Basic therapy with making use of antiinflammatory drugs, cardiac glycosides, diuretics together with drugs endowed with an antiarrhythmic activity and nitroglycerin (where indicated) was found to have practically no effect on LPO level or activity of the antioxidant system. The use of the drug kavergal, 1 g three times daily (total daily dosage being 3 g) in the complex therapy, has been shown to significantly decrease hyperlipoperoxidation both in the blood plasma and red cells increasing the activity of enzymes of the antioxidant defence.