Publications by authors named "F Sergent"
Article Synopsis
- Gestational trophoblastic diseases (GTD) include rare tumors related to pregnancy, with gestational choriocarcinoma (CC) being a highly aggressive type that can lead to high mortality if not treated quickly.
- CC has a higher incidence in molar pregnancies and poses greater risks in developing countries, with rates as high as 20 cases per 1,000 pregnancies.
- A new animal model for CC was created by injecting specific cancer cells into the placenta of pregnant mice, allowing researchers to mimic cancer development and metastasis, which highlights the role of placental blood vessels in spreading the tumor.
Ciguatoxins (CTXs) are marine neurotoxins that cause ciguatera poisoning (CP), mainly through the consumption of fish. The distribution of CTXs in fish is known to be unequal. Studies have shown that viscera accumulate more toxins than muscle, but little has been conducted on toxicity distribution in the flesh, which is the main edible part of fish, and the caudal muscle is also most commonly targeted for the monitoring of CTXs in the Canary Islands.
View Article and Find Full Text PDFArticle Synopsis
- Gestational choriocarcinoma (GC) is a serious tumor connected to hydatidiform moles, with NLRP7 being a key gene linked to its development and immune response.
- *Research shows that NLRP7 can operate through different pathways, significantly influencing cancer cell survival and aggressive traits in tumor cells compared to non-tumor cells.
- *Finding that NLRP7 plays a crucial role in GC growth suggests it could be a valuable target for new treatment strategies for resistant patients.
Purpose: Transvaginal ultrasound (TVUS) is used in routine practice to evaluate cervical length (CL). This technique is nevertheless invasive and often viewed as uncomfortable, which is less the case with transperineal ultrasound (TPUS). This study was conducted in light of recent technological improvements in the ultrasound field to evaluate whether TPUS could be used as an alternative to TVUS in CL assessment.
View Article and Find Full Text PDFArticle Synopsis
- Gestational choriocarcinoma (CC) is a serious type of cancer linked to abnormal pregnancies, often leading to metastasis and maternal mortality.
- Recent research indicates a connection between recurrent hydatidiform moles and mutations in the NLRP7 gene, which is involved in immune responses.
- NLRP7 is found to be overexpressed in CC cells, promoting immune tolerance and affecting cell behavior, which may contribute to both normal placentation and the aggressiveness of choriocarcinoma.