Publications by authors named "F Serana"
Article Synopsis
- Haemophagocytic lymphohistiocytosis (HLH) is a rare and severe immune system disorder characterized by excessive activation of immune cells, leading to tissue damage and potential multi-organ failure.
- A study examined pediatric patients suspected of having HLH by analyzing bone marrow samples and various biomarkers, finding significant differences in blood levels of hemoglobin, fibrinogen, triglycerides, ferritin, and lactate dehydrogenase (LD) between HLH patients and controls.
- The research concluded that blood biomarkers were more effective for diagnosing HLH than morphological evaluations, with specific cell types, particularly engorged red blood cells, showing the strongest diagnostic capabilities.
We report a novel case of SMARCD2 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily D, member 2) mutation successfully treated with hematopoietic stem cell transplantation. The female patient presented delayed cord separation, chronic diarrhea, skin abscesses, skeletal dysmorphisms, and neutropenia with specific granule deficiency. Analysis of the transcriptomic profile of peripheral blood sorted mature and immature SMARCD2 neutrophils showed defective maturation process that associated with altered expression of genes related to specific, azurophilic, and gelatinase granules, such as LTF, CRISP3, PTX3, and CHI3L1.
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- MIS-C is a serious condition in children linked to COVID-19 that leads to an overactive immune response.
- A study analyzed 40 MIS-C patients, finding that they had high inflammatory markers and altered immune cell types during different phases of the disease.
- Understanding the immune changes in MIS-C could guide better treatments for diseases caused by immune system dysfunction.
Anti-cytokine autoantibodies and, in particular, anti-type I interferons are increasingly described in association with immunodeficient, autoimmune, and immune-dysregulated conditions. Their presence in otherwise healthy individuals may result in a phenotype characterized by a predisposition to infections with several agents. For instance, anti-type I interferon autoantibodies are implicated in Coronavirus Disease 19 (COVID-19) pathogenesis and found preferentially in patients with critical disease.
View Article and Find Full Text PDFObjectives: Being COVID-19 convalescent plasma (CCP) a therapeutic option that can have a potential impact on the normalization of immunological parameters of COVID-19 affected patients, a detailed analysis of post-infusion immunological changes was conducted in CCP treated patients, aiming to identify possible predictive hallmarks of disease prognosis.
Methods: This prospective observational study describes a cohort of 28 patients who received CCP shortly after being hospitalized for COVID-19 and diagnosed for Acute Respiratory Distress Syndrome. All patients were subjected to a detailed flow cytometry based evaluation of immunological markers at baseline and on days +3 and +7 after transfusion.