Publications by authors named "F Seifert"

Article Synopsis
  • Fluorescing proteins that emit in the near-infrared region, particularly engineered phytochromes, are vital for biomedicine and life sciences, enabling in vivo monitoring of biological systems.
  • The study focuses on two minimal phytochromes, miRFP670nano3 and miRFP718nano, examining how their structural characteristics affect the fluorescence of the linked biliverdin chromophore.
  • Results indicate that the biliverdin is deprotonated at specific pyrrole rings in both proteins, with differing rates of proton exchange due to their structural dynamics, ultimately influencing their fluorescent efficiency.
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Background: Hypertension is a major risk factor for cardiovascular disease, affecting over a billion people worldwide. Mobile health (mHealth) apps have emerged as effective tools for managing hypertension, offering capabilities for monitoring blood pressure, fostering lifestyle changes, and improving treatment adherence.

Objective: This study aimed to explore patient-users' perspectives on the hypertension care mHealth app Hypertension.

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Purpose: This study aims to map the transmit magnetic field ( ) in the human body at 7T using MR fingerprinting (MRF), with a focus on achieving high accuracy and precision across a large dynamic range, particularly at low flip angles (FAs).

Methods: A FLASH-based MRF sequence (B1-MRF) with high sensitivity was developed. Phantom and in vivo abdominal imaging were performed at 7T, and the results were compared with established reference methods, including a slow but precise preparation-based method (PEX), saturated TurboFLASH (satTFL), actual flip angle imaging (AFI) and Bloch-Siegert shift (BSS).

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Cervical cancer is the fourth most common cancer in females. Genome-wide association studies (GWASs) have proposed cervical cancer susceptibility variants at the HLA locus on chromosome 6p21. To corroborate these findings and investigate their functional impact in cervical tissues and cell lines, we genotyped nine variants from cervical cancer GWASs (rs17190106, rs535777, rs1056429, rs2763979, rs143954678, rs113937848, rs3117027, rs3130214, and rs9477610) in a German hospital-based series of 1122 invasive cervical cancers, 1408 dysplasias, and 1196 healthy controls.

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