Publications by authors named "F Sciandra"
In recent years, the use of MXenes, a class of two-dimensional materials composed of transition metal carbides, nitrides, or carbonitrides, has shown significant promise in the field of skin wound healing. This review explores the multifunctional properties of MXenes, focusing on their electrical conductivity, photothermal effects, and biocompatibility in this field. MXenes have been utilized to develop advanced wound healing devices such as hydrogels, patches, and smart bandages for healing examination.
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- Dystroglycan (DG) is a receptor made up of α- and β-DG subunits, and a specific mutation in the β-DG subunit is linked to muscle-eye-brain disease in humans.
- In a mouse model with this mutation, many embryos do not survive to term, but those that do show normal early development but later develop muscle issues and changes in protein localization affecting the blood-brain barrier.
- The mutant mice have reduced levels of DG proteins in muscle and brain, making them a valuable model for studying the effects of β-DG alterations and the underlying mechanisms of a related disease.
In the current study, two series of novel thiazolidin-4-one benzenesulfonamide arylidene hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ agonistic activity. The phenethyl thiazolidin-4-one sulphonamide 9l showed the highest PPARɣ activation % by 41.7%.
View Article and Find Full Text PDFThe pressing need for multifunctional materials in medical settings encompasses a wide array of scenarios, necessitating specific tissue functionalities. A critical challenge is the occurrence of biofouling, particularly by contamination in surgical environments, a common cause of scaffolds impairment. Beyond the imperative to avoid infections, it is also essential to integrate scaffolds with living cells to allow for tissue regeneration, mediated by cell attachment.
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