The limit of anemia tolerance during hyperoxic ventilation with pure oxygen in anesthetized domestic pigs.

Background: During acellular replacement of an acute blood loss, hyperoxic ventilation (HV) increases the amount of O2 physically dissolved in the plasma and thereby improves O2 supply to the tissues. While this effect could be demonstrated for HV with inspiratory O2 fraction (FiO2) 0.6, it was unclear whether HV with pure oxygen (FiO2 1.

Hyperoxic ventilation increases the tolerance of acute normovolemic anemia in anesthetized pigs.

Objective: To investigate the impact of prophylactic hyperoxic ventilation with Fio2 0.6 on the physiologic limit of acute normovolemic anemia.

Design: Prospective, controlled, randomized experimental study.