Publications by authors named "F Schmidt-Graf"
Background: Glioblastoma's infiltrative growth and heterogeneity are influenced by neural, molecular, genetic, and immunological factors, with the precise origin of these tumors remaining elusive. Neurogenic zones might serve as the tumor stem cells' nest, with tumors in contact with these zones exhibiting worse outcomes and more aggressive growth patterns. This study aimed to determine if these characteristics are reflected in advanced imaging, specifically diffusion and perfusion data.
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- Molecular glioblastoma (molGB) is diagnosed as glioblastoma due to specific molecular markers, despite lacking typical grade 4 histological features, making it challenging to distinguish from lower-grade astrocytomas.
- Advanced imaging techniques revealed that molGB exhibited significantly higher relative cerebral blood volume (rCBV) and lower apparent diffusion coefficient (ADC) values compared to astrocytomas, indicating different tumor biology.
- The study suggests that quantitative imaging analysis could improve recognition of molGB in nonenhancing tumors, supporting the idea that molGB may represent an early stage of glioblastoma development.
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- Spatial intratumoral heterogeneity poses challenges for assessing glioblastoma treatment responses, but multimodal imaging and advanced analysis can help address this issue.
- A study categorized tumor voxels from 61 patients into true tumor progression or pseudoprogression using supervoxels and a Random Forest classifier, achieving 80% accuracy in identifying these categories.
- The analysis highlighted the importance of FET-PET features while also showing that other imaging factors like cerebral blood volume and T1-weighted imaging contributed significantly, guiding future personalized treatment strategies.
Article Synopsis
- This study investigates the relationship between glioblastoma (GBM) tumors and key neurogenic areas in the brain (SVZ and SGZ) to understand their impact on patient survival outcomes.
- Using advanced segmentation techniques, researchers analyzed data from 177 GBM patients and found that tumor proximity to the SVZ negatively correlated with survival, establishing a critical distance of 14 mm.
- Unlike previous studies, this research did not find significant relationships between SVZ contact and factors like tumor multifocality or MGMT promotor methylation, suggesting the need for more objective assessments in future GBM studies.
Borna disease virus 1 (BoDV-1) was just recently shown to cause predominantly fatal encephalitis in humans. Despite its rarity, bornavirus encephalitis (BVE) can be considered a model disease for encephalitic infections caused by neurotropic viruses and understanding its pathomechanism is of utmost relevance. Aim of this study was to compare the extent and distribution pattern of cerebral inflammation with the clinical course of disease, and individual therapeutic procedures.
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