Nerve Protection During Prostate Cryosurgery.

Cryosurgery is a minimally invasive approach to the treatment of focal prostate cancer (PCa). A major complication is the cryoinjury to the cavernous nerve in the neurovascular bundle (NVB). This nerve cryoinjury halts conduction of action potentials (APs) and can eventually result in erectile dysfunction and therefore diminished quality of life for the patient.

COVID-19: Has social isolation reduced the emission of pollutants in the megacity of São Paulo-Brazil?

Abstract: The first case of COVID-19 in Brazil was registered in the city of São Paulo on February 26, 2020; however, restrictive measures and social distancing were only determined in the city on March 17, 2020. A partial lockdown aimed to mitigate the advance of the virus by raising the social isolation rates, by limiting the operation of several services and the mobility of the population. Thus, this study aims to analyze the relationship between the social isolation index in the city of São Paulo and the emission levels of the main air pollutants (PM, PM, NO, NO, NO, SO and CO), as well as air temperature.

Association Between Somatostatin Receptor Expression and Clinical Outcomes in Neuroendocrine Tumors.

Objective: Somatostatin receptors (SSTRs), products of gene superfamily SSTR1-5, are commonly expressed in neuroendocrine tumors (NETs). Somatostatin analogs (SSAs) bind to SSTRs and are used as therapeutic agents in patients with advanced NETs. We hypothesized that tumor SSTR expression status would be associated with clinical outcomes in NET.

Tasquinimod modulates tumor-infiltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in bladder cancer.

The infiltration of myeloid cells helps tumors to overcome immune surveillance and imparts resistance to cancer immunotherapy. Thus, strategies to modulate the effects of these immune cells may offer a potential therapeutic benefit. We report here that tasquinimod, a novel immunotherapy which targets S100A9 signaling, reduces the immunosuppressive properties of myeloid cells in preclinical models of bladder cancer (BCa).

Somatostatin receptors in resected hepatocellular carcinoma: status and correlation with markers of poor prognosis.

Aims: To investigate the status of somatostatin receptors (SSTRs) in resected hepatocellular carcinoma (HCC).

Methods And Results: Transcript and protein levels of SSTR2, SSTR3 and SSTR5 were investigated, with real-time polymerase chain reaction (PCR) and manual and automated immunohistochemistry (IHC), in 53 resected HCCs and paired non-tumour tissues. SSTR1, SSTR4, SSTR5TMD4 and SSTR5TMD5 were analysed with real-time PCR.