Publications by authors named "F Schlott"
Article Synopsis
- Plexus injuries lead to chronic issues like paralysis, sensory loss, and pain, prompting interest in how the dorsal root ganglia (DRG) are affected following such injuries.
- A study involving 13 patients revealed that in about half, the typical cell structure of DRG was lost replaced by connective tissue, while others maintained their cellular integrity, although those with preserved neurons reported less pain.
- The findings suggest two distinct patient groups: those with neuronal preservation who might benefit from anti-inflammatory treatments, and those with neuronal loss needing further research for potential regenerative therapies.
Belatacept, Nulojix®, inhibits the interaction of CD28 on naïve T cells with B7.1/B7.2 (CD80/86) on antigen presenting cells, leading to T cell hyporesponsiveness and anergy and is approved as immunosuppressive drug in kidney transplantation.
View Article and Find Full Text PDFAdoptive T cell therapy (ACT) has become a treatment option for viral reactivations in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). Animal models have shown that pathogen-specific central memory T cells (TCM) are protective even at low numbers and show long-term survival, extensive proliferation and high plasticity after adoptive transfer. Concomitantly, our own recent clinical data demonstrate that minimal doses of purified (not in-vitro- expanded) human CMV epitope-specific T cells can be sufficient to clear viremia.
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- Human Cytomegalovirus (CMV) reactivation is a significant health issue for patients after organ transplants, and using CMV-specific T cell therapy shows promise despite challenges from CMV’s immune evasion.
- The study focuses on HLA-C*07:02, which allows for targeting specific CMV viral epitopes for more effective T cell therapy, showing high frequencies of these T cells in healthy individuals but with some complications relating to other immune cell interactions.
- A new double-staining technique improved the identification of true CMV-specific T cells, revealing a strong correlation between the identified T cells and their ability to secrete IFNγ, thus enhancing their potential for adoptive T cell therapy as a treatment approach.
Human Cytomegalovirus (CMV) can lead to primary infection or reactivation in CMV-seronegative or -seropositive kidney transplant recipients, respectively. Complications comprise severe end-organ diseases and acute or chronic transplant rejection. Risk for CMV manifestation is stratified according to the CMV-IgG-serostatus, with donor+/recipient- (D+/R-) patients carrying the highest risk for CMV-replication.
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