Publications by authors named "F Sarici"
Purpose: Eribulin mesylate is a non-taxane microtubule inhibitor which is a synthetic holichondrin B analog that can be used after anthracycline and taxane treatment in patients with metastatic breast cancer. We aimed to analyze the results of eribulin-trastuzumab combination in aggressively pretreated metastatic HER2-positive breast cancer patients.
Methods: In this single-center study, the records of 36 patients with HER-2-positive metastatic breast cancer who received at least one cycle of eribulin-trastuzumab in our clinic between 2015 and 2018 were analyzed retrospectively.
Purpose: Triple negative breast cancer (TNBC) is a heterogeneous disease group with a higher recurrence risk and poorer prognosis. In this study, we aimed to investigate the frequency and prognostic value of androgen receptor (AR) expression in tissues of TNBC patients.
Methods: A total of 84 TNBC patients treated between 2000 - 2015 in Hacettepe University Cancer Institute were included and their medical records were analyzed retrospectively.
Article Synopsis
- This study aims to explore how inflammatory markers impact prognosis in patients with metastatic breast cancer.
- During the study, 81 patients were monitored, revealing that high levels of C-reactive protein, ferritin, and beta-2 microglobulin were linked to significantly shorter overall survival compared to those with normal levels.
- The findings suggest that serum CRP, ferritin, and β2-M could serve as important indicators for predicting overall survival in metastatic breast cancer patients.
Cisplatin is an effective chemotherapeutic agent in the treatment of several types of malignant solid tumors but its clinical use is associated with ototoxicity. In the present study, we investigated the effect of selenium administration on lipid peroxidation (malondialdehyde [MDA]) and cisplatin-induced ototoxicity in rats. Healthy wistar albino rats (n = 21) were randomly divided into 3 groups: control (C), cisplatin (Cis), cisplatin and selenium (Cis+Se).
View Article and Find Full Text PDFPurpose: Educational status may be an important parameter in assessing breast cancer risk and prognosis. The purpose of this study was to investigate the correlation between the level of education and clinicopathological characteristics of breast cancer, including tumor grade, HER-2 and estrogen receptor (ER) status, tumor size, axillary lymph node involvement and metastasis.
Methods: The study included 1800 women who were diagnosed with invasive breast cancer during 2005-2013 at Hacettepe University Cancer Institute.