Publications by authors named "F Sansone"
Article Synopsis
- Cardiac hemangioma is a rare, benign tumor that can be asymptomatic or cause symptoms depending on its location and interaction with nearby structures.
- A case study describes a 79-year-old patient diagnosed with right cardiac hemangioma after experiencing severe symptoms like fluid buildup and heart failure.
- The tumor was successfully removed using cardiopulmonary bypass, leading to a favorable outcome after 12 months, highlighting its unusual size and location near the tricuspid valve.
Kidney diseases are a group of conditions related to the functioning of kidneys, which are in turn unable to properly filter waste and excessive fluids from the blood, resulting in the presence of dangerous levels of electrolytes, fluids, and waste substances in the human body, possibly leading to significant health effects. At the same time, the toxins amassing in the organism can lead to significant changes in breath composition, resulting in halitosis with peculiar features like the popular ammonia breath. Starting from this evidence, scientists have started to work on systems that can detect the presence of kidney diseases using a minimally invasive approach, minimizing the burden to the individuals, albeit providing clinicians with useful information about the disease's presence or its main related features.
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- Researchers are creating a deep learning algorithm to automatically segment thigh muscles and subcutaneous adipose tissue (SAT) from MRI scans of patients with muscular dystrophies.
- The study involved MRI imaging of 23 adult and pediatric patients from two hospitals in Italy, with manual segmentation done by an experienced radiologist for training the model.
- Two U-Net models were developed, achieving high accuracy in segmentation, with U-Net1 scoring a Dice similarity coefficient of 96.8% on training data, indicating strong potential for automated imaging in clinical settings.
Transthyretin (TTR) is an amyloidogenic homotetramer involved in the transport of thyroxine in blood and cerebrospinal fluid. To date, more than 130 TTR point mutations are known to destabilise the TTR tetramer, leading to its extracellular pathological aggregation accumulating in several organs, such as heart, peripheral and autonomic nerves, and leptomeninges. Tolcapone is an FDA-approved drug for Parkinson's disease that has been repurposed as a TTR stabiliser.
View Article and Find Full Text PDFIntroduction: A significant percentage of patients who survived the Coronavirus Infection Disease 2019 (COVID-19) showed persistent general and respiratory symptoms even months after recovery. This condition, called Post-Acute Sequelae of COVID-19 or Long-Covid syndrome (LCS), has been described also in children with positive history for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Little is known about the pathophysiologic mechanisms underlying this syndrome.
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