Publications by authors named "F Salvatori"
Article Synopsis
- Individuals with mutations in the ATM gene have an increased risk of atherosclerosis, likely due to impairments in endothelial function and oxidative stress caused by NADPH oxidase type 2.
- A study involving 27 children with ataxia telangiectasia (AT) and their parents showed that those with ATM mutations had worse endothelial function and higher oxidative stress markers compared to matched controls.
- Findings revealed that ATM-mutated individuals exhibited lower levels of nitric oxide bioavailability and faster thrombus formation, indicating a significant link between ATM mutations and cardiovascular risk factors.
Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease leading to progressive demyelination and neuronal loss, with extensive neurological symptoms. As one of the most widespread neurodegenerative disorders, with an age onset of about 30 years, it turns out to be a socio-health and economic issue, thus necessitating therapeutic interventions currently unavailable. Loss of integrity in the blood-brain barrier (BBB) is one of the distinct MS hallmarks.
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- The study investigates inherited genetic defects in blood coagulation, focusing on the coagulation factor V gene and how mutations affect clinical phenotypes, which can lead to either bleeding or thrombosis disorders.
- A family case study revealed a premature stop-codon mutation in the coagulation factor V gene that resulted in very low FV levels in the affected male, who experienced severe bleeding, while his father had a history of severe thrombosis.
- Advanced coagulation tests indicated that the family members exhibited varying responses to activated protein C, providing insights into their contrasting clinical outcomes despite shared genetic backgrounds.
Early detection of disease progression is a crucial issue in the management of cancer patients, especially in metastatic settings. Currently, treatment selection mostly relies on criteria based on radiologic evaluations (RECIST). The aim of the present retrospective study is to evaluate the potential inclusion of circulating tumor cells (CTCs) in hybrid criteria.
View Article and Find Full Text PDFSpontaneous abortion is a pregnancy complication characterized by complex and multifactorial etiology. About 5% of childbearing women are globally affected by early pregnancy loss (EPL) and most of them experience recurrence (RPL). Epigenetic mechanisms and controlled inflammation are crucial for pregnancy maintenance and genetic predispositions may increase the risk affecting the maternal-fetal crosstalk.
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