A nephrogenic mechanism underlies dexmedetomidine-induced polyuria. A case report.

Dexmedetomidine's α-adrenoreceptor agonism has been gaining popularity in the anesthetic room as a sedative-hypnotic and analgesic agent, and with extensive perioperative use rising concern about side effects is necessary. Bradycardia and hypotension are common adverse effects, but there are also several reports of excessive urine output, possibly due to vasopressin secretion and permeability of collecting ducts. Polyuria usually resolves with discontinuation of the drug, and significant morbidity has not been reported.

Misinterpretation and Limitations of pEEG Monitoring During Multimodal General Anesthesia: A Case Report.

The adequate titration of hypnotic agents can be achieved using processed electroencephalogram (pEEG) monitors. pEEG monitors with a spectrogram, such as bilateral bispectral index (BIS), are useful because they can show different signatures that suggest the effect of a given drug on brain activity. Multimodal general anesthesia is based on a combination of hypnotic and antinociceptive agents.