Publications by authors named "F Salabi"
Article Synopsis
- Scorpion venom is rich in biologically active peptides and proteins, leading researchers to analyze the venom gland transcriptome of a specific Iranian scorpion to explore medicinal applications and antivenom production.
- The study used advanced techniques such as Illumina RNA-Seq and bioinformatics to provide a high-quality assembly of 101,180 transcripts from the venom gland, showing a significant presence of complete arthropod BUSCOs.
- The analysis identified a variety of active peptides and proteins relevant to neurology and inflammation, including ion channel inhibitors, neurotoxins, and different isoforms of a specific venom peptide named HzLVP1.
Article Synopsis
- Scorpion stings are a major public health issue, especially in tropical and subtropical areas, with varying venom profiles leading to different symptoms of envenomation.
- Scorpion venoms contain unique peptides that could be valuable for drug development, prompting the need for a database cataloging scorpion species and their venom components.
- ScorpDb is a new database focused on Iranian scorpions, providing research access to venom data and symptoms, with plans to expand to include more varieties of scorpions in the future.
Research has shown that voraxin α derived from male ticks stimulates blood feeding to engorge in female ticks. Whereas, the oviposition rate, egg weight, and body weight of female ticks were reduced in animals vaccinated with recombinant (r-) voraxin α. These data suggest a potential role of r-voraxin α as a functional anti-tick antigen in Rhipicephalus appendiculatus and Amblyomma hebraeum tick infestation.
View Article and Find Full Text PDFRecently, RNA sequencing has been widely applied to deeply understand the molecular diversity of the venom compounds of various venomous animal species, including scorpions. Among the venomous scorpion species of the Buthidae family, there are many documents of stinging and severe envenoming of victims by the scorpion of . We present here a high-throughput RNA sequencing dataset of the venom glands from five individuals, including male and female scorpions.
View Article and Find Full Text PDFPhospholipase A2 is the most abundant venom gland enzyme, whose activity leads to the activation of the inflammatory response by accumulating lipid mediators. This study aimed to identify, classify, and investigate the properties of venom PLA2 isoforms. Then, the present findings were confirmed by chemically measuring the activity of PLA2.
View Article and Find Full Text PDF