Publications by authors named "F Saavedra"
Article Synopsis
- Genetic and environmental factors contribute to neural tube defects (NTD), notably influenced by the presence of Scavenger Receptor Class B Type 1 (SR-B1) in mouse embryos, where its absence leads to high rates of exencephaly that can be prevented with vitamin E.
- In the study, female mice with SR-B1 were given a high-fat/high-sugar diet to examine its impact on vitamin E levels and oxidative stress in both the mothers and their embryos, along with the incidence of NTD.
- Results showed that the HFHS diet caused metabolic changes and increased NTD rates in embryos, but vitamin E supplementation successfully reduced oxidative stress and improved lipid management in the developing embryos, preventing malformations entirely.
Article Synopsis
- Genome instability is linked to histone imbalances affecting DNA integrity, and histones must be properly synthesized and modified before entering the nucleus to ensure chromatin assembly.
- The histone demethylase JMJD1B is essential for supplying adequate histones H3 and H4, and its reduced levels in melanoma cells lead to cytoplasmic accumulation of histones, causing chromatin assembly defects and increased DNA damage.
- Research shows that JMJD1B knockout in melanoma cells enhances their tumorigenic properties and correlates with higher genome instability, indicating that JMJD1B plays a crucial role in maintaining genome integrity and may act as a safeguard against oncogenic mutations.
Animals can adjust their diet to maximize energy or nutritional intake. For example, birds often target fruits that match their beak size because those fruits can be consumed more efficiently. We hypothesized that pressure to optimize diet-measured as matching between fruit and beak size-increases under stressful environments, such as those that determine species' range edges.
View Article and Find Full Text PDFMarine plastic pollution remains one of the greatest problems worldwide. Hence, this study explores the attitudes and pro-environmental behaviors of Peruvian and Chilean citizens regarding marine pollution, with an emphasis on plastic pollution. For this, forty-four semi-structured interviews were conducted with Peruvian ( = 24) and Chilean ( = 20) citizens, of which, through thematic analysis, semantic patterns were identified.
View Article and Find Full Text PDF