Publications by authors named "F SOKOL"
Patient-derived xenografts (PDXs) can be improved by implantation of a humanized niche. Nevertheless, the overall complexity of the current protocols, as well as the use of specific biomaterials and procedures, limits the wider adoption of this approach. Here, we identify the essential minimum steps required to create the humanized scaffolds and achieve successful acute myeloid leukemia (AML) engraftment.
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- - The study focuses on classic Hodgkin lymphoma (cHL), a common B-cell cancer, emphasizing that while many patients achieve remission with standard therapies, some relapse or have refractory disease, which raises concerns about long-term prognosis.
- - Researchers conducted a retrospective analysis involving 120 patients to study the relationship between PD-L1 expression on Hodgkin-Reed-Sternberg cells and patient outcomes, with a median follow-up of 90 months.
- - Results revealed that patients with positive PD-L1 expression had a higher relapse/refractory rate (28%) compared to those with negative expression, who did not experience any relapses, indicating that PD-L1 positivity is associated with poorer outcomes in cHL.
Diagnosis and assessment of patients with prostate cancer is dependent on accurate interpretation and grading of histopathology. However, morphology does not necessarily reflect the complex biological changes occurring in prostate cancer disease progression, and current biomarkers have demonstrated limited clinical utility in patient assessment. This study aimed to develop biomarkers that accurately define prostate cancer biology by distinguishing specific pathological features that enable reliable interpretation of pathology for accurate Gleason grading of patients.
View Article and Find Full Text PDFBackground/aim: Glioblastoma (GBM) is one of the deadliest human cancers responding very poorly to therapy. Although the central nervous system has been traditionally considered an immunologically privileged site with an enhanced immune response, GBM appears to benefit from this immunosuppressive milieu. Immunomodulatory molecules play an important role in immune tumor-host interactions.
View Article and Find Full Text PDFCastlemans disease is the term for reactive lymphocytary and plasmocytary proliferation which occurs in the unicentric (localized) form, usually without systemic symptoms, or in the generalized/multicentric form, typically with systemic symptoms (www.vzacne-diagnozy.cz).
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