Low-Concentration Hypochlorous Acid Drinking Water Alleviates Broiler Gut Microbial Load While Preserving Overall Growth Performance.

Hypochlorous acid has been attempted as an additive to animal drinking water in practical animal farming processes for water microbial quality control. Despite its potential, there is still a knowledge gap concerning the effects of hypochlorous acid on both poultry growth performance and gut microbial load. To address this gap, an animal study was conducted using flow cytometry to quantify the age-related microbial load in broiler manure and gut contents.

Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia.

Background: Intermediate phenotypes, such as characteristic neuroimaging patterns, offer unique insights into the genetic and stress-related underpinnings of neuropsychiatric disorders like depression. This study aimed to identify neuroimaging intermediate phenotypes associated with depression, bridging etiological factors to behavioral manifestations and connecting insights from animal models to diverse clinical populations.

Methods: We analyzed datasets from both rodents and humans.

Malaria: Factors affecting disease severity, immune evasion mechanisms, and reversal of immune inhibition to enhance vaccine efficacy.

Malaria is a complex parasitic disease caused by species of Plasmodium parasites. Infection with the parasites can lead to a spectrum of symptoms and disease severity, influenced by various parasite, host, and environmental factors. There have been some successes in developing vaccines against the disease recently, but the vaccine efficacies require improvement.

[Analysis of ischemic stroke biomarkers based on non-targeted metabolomics].

Biomarkers for ischemic stroke (IS) are yet to fulfill clinical requirements. This study used non-targeted metabolomics to investigate differential metabolites and metabolic pathways in plasma and brain tissue following IS, with the aim of identifying new potential biomarkers and therapeutic targets. Twelve Tibetan miniature pigs were randomly assigned to a model- or sham-operation group.

Highly Accessible Electrocatalyst with Formed Copper-Cluster Active Sites for Enhanced Nitrate-to-Ammonia Conversion.

Ammonia synthesis via nitrate electroreduction is more attractive and sustainable than the energy-extensive Haber-Bosch process and intrinsically sluggish nitrogen electroreduction. Herein, we have designed a single-site Cu catalyst on hierarchical nitrogen-doped carbon nanocage support (Cu/hNCNC) for nitrate electroreduction, which achieves an ultrahigh ammonia yield rate (YR) of 99.4 mol h g (2.