Publications by authors named "F S Nakao"
Selinexor, a first-in-class exportin1 (XPO1) inhibitor, is an attractive anti-tumor agent because of its unique mechanisms of action; however, its dose-dependent toxicity and lack of biomarkers preclude its wide use in clinical applications. To identify key molecules/pathways regulating selinexor sensitivity, we performed genome-wide CRISPR/Cas9 dropout screens using two B-ALL lines. We identified, for the first time, that paralogous DDX19A and DDX19B RNA helicases modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export.
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- * Analyzing 111 lesions from 168 patients, the research found three key geometric parameters—SB diameter, BP-CT length, and dPOC—that were significant predictors of SB compromise, with corresponding cutoff values established.
- * The results revealed that as the OCT risk score increased based on these parameters, the likelihood of SB compromise also increased significantly, demonstrating the predictive capability of OCT in this context.