Publications by authors named "F S Lumertz"
Association between hair cortisol concentration and acute stress symptoms in family members of critically ill patients: a cross-sectional study.
Crit Care Sci
October 2024
Article Synopsis
- - The study aimed to explore the link between hair cortisol levels and acute stress symptoms in family members of critically ill patients in Brazil.
- - Researchers surveyed 110 family members, revealing that 80% experienced acute stress symptoms, but found no significant difference in cortisol levels between stressed and non-stressed individuals (p = 0.419).
- - The only factor significantly related to stress symptoms was the patient's alertness during the interview, indicating that prior cortisol levels may not predict acute stress in these family members.
Article Synopsis
- Exposure to stress, especially prenatal stress (PNS), can lead to long-term behavioral and biological changes that may increase the risk of developing mental disorders, but responses to stress vary among individuals.
- In a study with rats, PNS-exposed adolescents showed signs of emotional issues like anxiety and lack of pleasure, with 70% categorized as vulnerable to stress and 30% as resilient.
- The research also indicated that resilient males have different brain activation patterns compared to vulnerable ones, suggesting that understanding these differences could help in creating new treatment approaches for stress-related disorders.
A systematic review and multilevel meta-analysis of the prenatal and early life stress effects on rodent microglia, astrocyte, and oligodendrocyte density and morphology.
Neurosci Biobehav Rev
July 2023
Article Synopsis
- * A systematic review and meta-analysis of rodent studies found that prenatal stress (PNS) led to increased microglia density and decreased oligodendrocyte density, while early life stress (ELS) enlarged microglia cell size.
- * The analysis revealed that factors like the type of stress, age, and sex of the animals influenced the results, highlighting the significance of glial cell changes in understanding stress-related issues throughout development.
Exposure to early life stress (ELS) may lead to long-lasting neurobiological and behavioral impairments. Alterations in the immune system and neuroinflammatory state induced by ELS exposure are considered risk factors for developing psychiatric disorders. Here, we performed a systematic review and meta-analysis of rodent studies investigating the short and long-term effects of ELS exposure on anti and pro-inflammatory cytokines in brain tissues.
View Article and Find Full Text PDFSocial isolation (SI) stress results from a combination of intrinsic and environmental factors and is associated with a variety of negative developmental outcomes. Oxytocin (OXT) might play a role in the consequences of SI in the brain and periphery. We conducted a systematic review and meta-analysis to compile data about the effects of SI in the oxytocinergic system of rats and mice, and its relation to behavioral alterations.
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