Publications by authors named "F S Larin"

Aim: Evaluation of epidemic situation by non-poliomyelitis enterovirus infections in Krasnodar region in multi-year dynamics and characterization of clinical course of enterovirus serous meningitis in hospitalize patients.

Materials And Methods: Retrospective analysis of non-poliomyelitis enterovirus infection epidemi process manifestations during 2002-2012 in Krasnodar region territory based on data of Center of Hygien and Epidemiology in Krasnodar Region.

Results: Clinical-epidemiologic characteristics of enterovirus infections in Krasnodar region are presented.

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The analysis of the morbidity dynamics of HIV infection, hepatitis B and C in the Krasnodar territory for 1996-2003 is presented. The tendency of strengthening direct correlation between age-dependent rates in these groups of diseases has been established. The correlation coefficient (rxy) is at present +0.

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It has been found that hydroxylated pyrimidine derivatives actively participate in metabolic proceeds related to functioning of vitamin B1-dependent enzymes (transketolase, 2-oxo acid dehydrogenase). Hydroxypyrimidines also induce a significant increase in the levels of total lipids and cholesterol in the mice liver, not changing the phospholipid content.

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The effect of pyrazole (360 mg/kg, intraperitoneally) on the levels of lipid fractions was studied in the rat liver and brain. There were no differences in hepatic lipid levels after administration of pyrazole alone and in combination with ethanol (20% solution, 1 g/ kg body weight, intragastrically). Pyrazole alone or in combination with alcohol elevates the concentrations of cholesterol, total phospholipids, phosphatidylethanolamine, and cerebrosides III, reduces the levels of sphingomyelin and cardiolipin.

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The authors have studied the influence of additional introduction into the ration of sunflower oil on fatty-acid composition of erythrocytic membranes in chronic alcoholics. The computerized discriminant analysis has evidenced that additional introduction of sunflower oil into the ration of the patients normalizes the fatty-acid spectrum of erythrocytic membranes. Besides that, enrichment of the ration with linoleic acid improves the parameters characterizing the liver function (bilirubin, alanine aminotransferase of blood serum).

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