Publications by authors named "F S Ige"
Population-based study is known to be a very essential type of study during and after a pandemic or epidemic, as it provides crucial information on the incidence, prevalence, and risk factors of the disease in question. There has been limited information about the challenges faced in conducting such surveys in Nigeria. In this paper, we will share our experience, and describe the challenges faced in conducting a population-based seroepidemiological study of COVID-19 in Lagos, Nigeria.
View Article and Find Full Text PDFHealthcare workers (HCWs) are disproportionately infected with SARS-CoV-2 when compared to members of the general public; estimating the seroprevalence of SARS-CoV-2 antibody and SARS-CoV-2 infection rate among HCWs is therefore crucial. This study was carried out in four health facilities in Lagos Nigeria to determine the prevalence of IgG antibodies (seroprevalence) and SARS-CoV-2 active infection rate via a positive rtPCR result, the cross-sectional study was conducted between December 2020 and July 2021. Nasopharyngeal and blood samples were collected from HCWs and screened for SARS-CoV-2 infection using the rtPCR technique and antibody using the Abbott anti-SARS-CoV-2 IgG CMIA assay, respectively.
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- * A study conducted in Nigeria's Enugu, Gombe, Lagos, and Nasarawa states found that seroprevalence of SARS-CoV-2 antibodies ranged from 9.3% to 25.2%, with over 96% of interviewed individuals providing blood samples
- * Despite a high seroprevalence indicating infection rates much higher than officially reported cases, active SARS-CoV-2 infection was low at 0.2%, suggesting that most of the population remained susceptible to COVID-19
Article Synopsis
- The study aimed to assess the effectiveness of different SARS-CoV-2 IgG assays in Nigeria, where malaria is common, to get a better estimate of COVID-19 prevalence.
- Researchers tested four assays on plasma samples from COVID-19 positive and pre-pandemic individuals, finding that multi-antigen assays had higher sensitivity compared to a single-antigen assay.
- The findings suggest that multi-antigen tests can accurately measure COVID-19 seroprevalence in regions affected by malaria, potentially improving understanding of vaccine effectiveness.
Real-world data on vaccine-elicited neutralising antibody responses for two-dose AZD1222 in African populations are limited. We assessed baseline SARS-CoV-2 seroprevalence and levels of protective neutralizing antibodies prior to vaccination rollout using binding antibodies analysis coupled with pseudotyped virus neutralisation assays in two cohorts from West Africa: Nigerian healthcare workers (n = 140) and a Ghanaian community cohort (n = 527) pre and post vaccination. We found 44 and 28% of pre-vaccination participants showed IgG anti-N positivity, increasing to 59 and 39% respectively with anti-receptor binding domain (RBD) IgG-specific antibodies.
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