Publications by authors named "F S Filev"
Background: The quality of the endothelial cell layer is a major criterion for the approval of organ-cultured human donor-corneas for transplantation. We wanted to compare the predictive capacities of initial endothelial density and endothelium cell morphology for the approval of donor corneas for transplantation and for the clinical outcome after transplantation.
Methods: The endothelial density and endothelium morphology in organ culture were examined by semiautomatic assessment of 1031 donor corneas.
In this experimental study we used for the first time Tiprotec as a solution for corneal preservation and cold storage. We compared the resultant endothelial cell morphology and viability with this obtained after preservation of the ex-vivo corneas with both usual standard techniques: conventional cold storage (using Eusol-C) and organ culture. This prospective, in vitro, 3-armed parallel study was performed with the use of 90 porcine corneas (examined for their endothelial quality and transparency) randomly selected for preservation in three storage methods (each 30 corneas): organ culture, standard cold storage (Eusol-C) and experimental cold storage (Tiprotec) Endothelium cell quantity and quality as well as corneal opacification were assessed.
View Article and Find Full Text PDFPurpose: To review the clinical outcome of keratoconus patients after excimer laser treatment with combined riboflavin UV-A collagen crosslinking (CXL) treatment was reviewed in light of the UDVA, CDVA and HOA.
Methods: Following a PubMed-based literature review of studies on excimer laser treatment with combined riboflavin UV-A CXL published between 2009 and 2018, peer-reviewed English-written studies were evaluated using the GRADE approach ( www.gradeworkinggroup.
Article Synopsis
- A significant number of myopic patients had radial keratotomy (RK) in the past, but this procedure often led to unpredictable long-term refractive outcomes, prompting the need for additional treatments.
- This study analyzed 16 eyes that underwent topography-guided photorefractive keratotomy (PRK) to correct residual errors after RK, with a follow-up period averaging 41 months.
- The results indicated improved uncorrected visual acuity in all cases and stable refraction, suggesting that PRK is a viable option for addressing secondary vision issues following RK, though patient education on the procedure's limitations remains crucial.