Publications by authors named "F Russano"
Article Synopsis
- Basal cell carcinomas (BCCs) are common skin cancers that can cause local damage but have a low risk of death; traditional treatments include surgery, radiotherapy, and chemotherapy.
- Electrochemotherapy (ECT) is a newer treatment that uses electrical stimulation to enhance drug delivery directly into cancer cells, showing promising results for BCC.
- A case report of a 68-year-old man demonstrated that ECT led to complete recovery and improved quality of life, making it a viable alternative or addition to standard surgical options for BCC treatment.
In-transit metastases (ITM) in melanoma present a significant therapeutic challenge due to their advanced stage and complex clinical nature. From traditional management with surgical resection, ITM treatment has evolved with the advent of systemic therapies such as immune checkpoint inhibitors and targeted therapies, which have markedly improved survival outcomes. This study aims to review and highlight the efficacy of both systemic and locoregional treatment approaches for ITM.
View Article and Find Full Text PDFBackground: Isolated limb hyperthermic-antiblastic perfusion (ILP) was the most effective local treatment for advanced in-transit melanoma, but the advent of modern effective immunotherapy (IT), such as immune checkpoint inhibitors, has changed the treatment landscape.
Methods: This study evaluated the role of the association between ILP and IT in the treatment of locally advanced unresectable melanoma, particularly in relation to modern systemic therapies. We analyzed 187 consecutive patients who were treated with ILP (melphalan or melphalan associated with TNF-alpha) for advanced melanoma at the Veneto Institute of Oncology of Padua (Italy) and the Padua University Hospital (Italy) between June 1989 and September 2021.
Article Synopsis
- Kaposi's sarcoma (KS) is a rare tumor with four clinical forms, diagnosed through histopathological and immunohistochemical analyses, and treated using a mix of local and systemic methods.
- A retrospective study analyzed 86 KS patients treated over 29 years, showing that most were male and had the classical variant, with surgery and chemotherapy being the common treatments.
- The study found a persistent treatment response in about 65% of patients, a 22% relapse rate, and an overall survival rate of 90% to 70% over 2 to 10 years, emphasizing the need for a multidisciplinary approach to manage the disease effectively.
Isolated limb perfusion (ILP) involves the local administration of high doses of anticancer drugs into a limb affected by unresectable locally advanced tumors (with special regard to in-transit melanoma metastases), minimizing systemic side effects. Tumor response to anticancer drugs may depend on the expression of apoptosis-related genes, such as SURVIVIN and MDM2. This retrospective cohort study investigated the association between tumor SURVIVIN and MDM2 expression levels and treatment response or clinical outcomes in patients undergoing ILP for in-transit melanoma metastases.
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