Publications by authors named "F Ruschitzka"
Transthoracic Echocardiography (TTE) is a crucial tool for assessing cardiac morphology and function quickly and non-invasively without ionising radiation. However, the examination is subject to intra- and inter-user variability and recordings are often limited to 2D imaging and assessments of end-diastolic and end-systolic volumes. We have developed a novel, fully automated machine learning-based framework to generate a personalised 4D (3D plus time) model of the left ventricular (LV) blood pool with high temporal resolution.
View Article and Find Full Text PDFBackground And Aims: Systemic sclerosis (SSc) is a systemic autoimmune disease, characterized by widespread microvasculopathy and fibrosis. Vascular and endothelial cell changes appear to precede other features of SSc. Retinal vascular analysis is a new, easy-to-use tool for the assessment of retinal microvascular function.
View Article and Find Full Text PDFWhile immune checkpoint inhibitors (ICIs) have revolutionized modern oncology, they are also associated with immune-related adverse events (irAEs). Previous histopathological descriptions of organ-related inflammatory changes do not consider systemic effects of ICIs, because of an absence of comprehensive autopsy studies. We performed a retrospective study on 42 whole-body autopsies of patients treated with ICIs from January 2011 to March 2024 to determine frequency, organ distribution and morphology of ICIs-associated inflammatory changes as well as their clinical relevance.
View Article and Find Full Text PDFBackground: The mechanism of how sacubitril/valsartan improves outcomes in heart failure with reduced ejection fraction (HFrEF) is still incompletely understood.
Objectives: The aim of this trial was to delineate the effects of sacubitril/valsartan on endothelial function, retinal microvascular function, and arterial stiffness in HFrEF.
Methods: This double-blind controlled trial randomized 79 stable HFrEF patients with NYHA class II-IV on guideline-recommended therapy (mean age: 59.
Article Synopsis
- - The study evaluated cardiologists' awareness and implementation of advanced heart failure (HF) guidelines, revealing significant knowledge gaps, especially among general cardiologists and other participants compared to heart failure specialists.
- - An online survey collected data from 497 cardiologists across Europe, highlighting that 84% of heart failure cardiologists regularly used ESC/HFA criteria for advanced HF, while only 44% of general cardiologists did.
- - The findings emphasize the need for increased education on advanced HF guidelines and improvements in the referral process to ensure patients receive timely and appropriate care.