Bayesian Assessment of Corrosion-Related Failures in Steel Pipelines.

The probability of gas escapes from steel pipelines due to different types of corrosion is studied with real failure data from an urban gas distribution network. Both the design and maintenance of the network are considered, identifying and estimating (in a Bayesian framework) an elementary multinomial model in the first case, and a more sophisticated non-homogeneous Poisson process in the second case. Special attention is paid to the elicitation of the experts' opinions.

Generative Bayesian Computation for Maximum Expected Utility.

Generative Bayesian Computation (GBC) methods are developed to provide an efficient computational solution for maximum expected utility (MEU). We propose a density-free generative method based on quantiles that naturally calculates expected utility as a marginal of posterior quantiles. Our approach uses a deep quantile neural estimator to directly simulate distributional utilities.

Hierarchical Protofilament Intertwining Rules the Formation of Mixed-Curvature Amyloid Polymorphs.

Amyloid polymorphism is a hallmark of almost all amyloid species, yet the mechanisms underlying the formation of amyloid polymorphs and their complex architectures remain elusive. Commonly, two main mesoscopic topologies are found in amyloid polymorphs characterized by non-zero Gaussian and mean curvatures: twisted ribbons and helical fibrils, respectively. Here, a rich heterogeneity of configurations is demonstrated on insulin amyloid fibrils, where protofilament packing can occur, besides the common polymorphs, also in a combined mode forming mixed-curvature polymorphs.

Gate Electrodes Enable Tunable Nanofluidic Particle Traps.

The ability to control the location of nanoscale objects in liquids is essential for fundamental and applied research from nanofluidics to molecular biology. To overcome their random Brownian motion, the electrostatic fluid trap creates local minima in potential energy by shaping electrostatic interactions with a tailored wall topography. However, this strategy is inherently static; once fabricated, the potential wells cannot be modulated.