Publications by authors named "F Rozenberg"
The genetic basis of resistance to quinine (QN), a drug used to treat severe malaria, has long been enigmatic. To gain further insight, we used FRG-NOD human liver-chimeric mice to conduct a genetic cross between QN-sensitive and QN-resistant parasites, which also differ in their susceptibility to chloroquine (CQ). By applying different selective conditions to progeny pools prior to cloning, we recovered 120 unique recombinant progeny.
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- * A study examined 131 female patients with X-linked dominant incontinentia pigmenti (IP), finding that 36% produced autoantibodies against IFN-α and/or IFN-ω, significantly higher than age-matched controls.
- * The presence of these autoantibodies is linked to an abnormally small thymus and predisposes patients to life-threatening viral infections, while those without these autoantibodies do not face the same risk.
Bacterial sexually transmitted infections (BSTIs) are largely preventable, yet their rates remain high across the U.S., particularly among sexual minority men (SMM) living with HIV (LWH).
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- The study identifies two cases of herpes simplex virus 1 (HSV-1) encephalitis in children linked to rare genetic variants of the TMEFF1 gene, which plays a protective role in the brain.
- TMEFF1 protein interacts with the HSV-1 receptor NECTIN-1, blocking the virus's ability to enter brain cells, but genetic deficiencies in TMEFF1 allow for easier viral entry and replication within neurons.
- The research suggests that enhancing TMEFF1 levels or using type I interferon can restore resistance to HSV-1, indicating a potential therapeutic pathway for preventing HSV-1 encephalitis.