Publications by authors named "F Rosenberger"
Aberration of mitochondrial function is a shared feature of many human pathologies, characterised by changes in metabolic flux, cellular energetics, morphology, composition, and dynamics of the mitochondrial network. While some of these changes serve as compensatory mechanisms to maintain cellular homeostasis, their chronic activation can permanently affect cellular metabolism and signalling, ultimately impairing cell function. Here, we use a Drosophila melanogaster model expressing a proofreading-deficient mtDNA polymerase (POLγ) in a genetic screen to find genes that mitigate the harmful accumulation of mtDNA mutations.
View Article and Find Full Text PDFPurpose: In resistance training (RT), the change in volume-load from training sessions (TS) to TS is an indicator of training progress. Resulting growth trajectories are likely to differ between individuals. Understanding this variation is important for exercise planning in general, but even more for clinical populations.
View Article and Find Full Text PDFArticle Synopsis
- Lung adenocarcinoma is a serious cancer that is a major cause of death globally, and this study examines how mitochondrial DNA (mtDNA) copy number impacts tumor growth in mice.
- Increased mtDNA levels were found in lung tumors caused by KRAS expression, leading to larger tumors in mice with higher mtDNA and reduced growth when mtDNA was depleted.
- The findings suggest mtDNA copy number is critical for lung cancer progression and could pave the way for new cancer treatments, while immune responses in the lung remained unaffected by mtDNA levels.
Article Synopsis
- Toxic epidermal necrolysis (TEN) is a severe and potentially deadly skin reaction caused by common medications, featuring rapid skin detachment due to cell death, with no effective treatments currently available.
- Researchers used deep visual proteomics to analyze skin biopsies from TEN patients, identifying significant changes in proteins related to type I and II interferon signaling and activated phosphorylated STAT1, which are believed to drive the condition.
- The study found that using JAK inhibitors, like tofacitinib and baricitinib, effectively reduced skin damage in both mouse models and human patients with TEN, indicating these pathways could be targeted for potential new treatments.
Colorectal adenomas (CRAs) are potential precursor lesions to adenocarcinomas, currently classified by morphological features. We aimed to establish a molecular feature-based risk allocation framework toward improved patient stratification. Deep visual proteomics (DVP) is an approach that combines image-based artificial intelligence with automated microdissection and ultra-high sensitive mass spectrometry.
View Article and Find Full Text PDF