Publications by authors named "F Rogers"

Increasing trauma center admission volume is said to decrease mortality. Evidence supporting this position is dependent upon patient groups and the time period studied, and gaps remain. We evaluated the effect of annual volume of critically injured patients on hospital mortality, comparing two time periods.

View Article and Find Full Text PDF

This real-world study explored factors affecting persistence with macitentan and selexipag treatment from the perspective of 23 healthcare professionals (HCPs) and 134 patients with pulmonary arterial hypertension between 2019 and 2022. Continuous patient/HCP communication and education were key drivers of persistence, as were early discussion and management of side effects.

View Article and Find Full Text PDF
Article Synopsis
  • Monoclonal antibody therapies for cancer have seen significant success but are primarily focused on specific cell surface antigens, leaving many potential targets inside cells untapped.
  • Recent research has focused on humanizing a lupus-derived autoantibody, 3E10, which can penetrate cells and target tumors effectively.
  • The study found that the efficiency of this cell uptake relies on a specific transporter and that a particular human variant of 3E10 retains the ability to bind to RAD51, potentially enhancing cancer treatment by inhibiting DNA repair mechanisms.
View Article and Find Full Text PDF

Introduction: There is a high prevalence of cognitive difficulties in MS, but despite this, there are few programmes targeting cognition that focus on the ability to function well in everyday life. The Cognitive Occupation-Based programme for people with Multiple Sclerosis (COB-MS), an occupation-focused cognitive intervention, was developed to address this. It addresses both the functional difficulties and the wide-ranging symptoms that present in MS.

View Article and Find Full Text PDF

When pregnant patients are involved in traumatic incidents, the trauma clinician encounters two patients-both the mother and the unborn child. Advanced trauma life support dictates that the first priority is the life of the mother; however, there are rare situations where to provide the greatest chance of survival for both the mother and baby, an emergency cesarean section (perimortem cesarean delivery [PMCD]) must be performed. The decision to perform this procedure must occur quickly, and the reality is that a board-certified obstetrician is rarely present, particularly in rural areas.

View Article and Find Full Text PDF