Publications by authors named "F Rogerio"
Focal cortical dysplasia (FCD) is a neurodevelopmental condition characterized by malformations of the cerebral cortex that often cause drug-resistant epilepsy. In this study, we performed multi-omics single-nuclei profiling to map the chromatin accessibility and transcriptome landscapes of FCD type II, generating a comprehensive multimodal single-nuclei dataset comprising 61,525 cells from 11 clinical samples of lesions and controls. Our findings revealed profound chromatin, transcriptomic, and cellular alterations affecting neuronal and glial cells in FCD lesions, including the selective loss of upper-layer excitatory neurons, significant expansion of oligodendrocytes and immature astrocytic populations, and a distinct neuronal subpopulation harboring dysmorphic neurons.
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- The study investigates the role of the mitochondrial protein NNT in obesity-related metabolic issues, using a specific mouse model lacking NNT genetic material.
- Unlike previous studies, this research utilized a high-fat diet (45% calories from fat) that better represents typical fat-rich diets compared to the usual 60%.
- Results show that mice without NNT gained less weight on a high-fat diet but had poorer glucose tolerance, while also revealing an increase in brown adipose tissue mass and inflammatory markers in the hypothalamus associated with diet-induced inflammation.
Article Synopsis
- * A case involving a 57-year-old man with a significant smoking history revealed he had a poorly differentiated tumor in his left tonsil, which was linked to a lung lesion after further testing.
- * The findings stress the need for early detection of oral metastases from lung cancers to facilitate timely and effective treatment.
Focal cortical dysplasia (FCD) is a brain malformation that causes medically refractory epilepsy. FCD is classified into three categories based on structural and cellular abnormalities, with FCD type II being the most common and characterized by disrupted organization of the cortex and abnormal neuronal development. In this study, we employed cell-type deconvolution and single-cell signatures to analyze bulk RNA-seq from multiple transcriptomic studies, aiming to characterize the cellular composition of brain lesions in patients with FCD IIa and IIb subtypes.
View Article and Find Full Text PDFMaize (Zea mays) is one of the most important crops worldwide, and fungal diseases are responsible for major losses in food production. Anthracnose caused by Colletotrichum graminicola can infect all maize tissues, although stalk rot and seedling blight cause more significant economic damage (Munkvold and White, 2016). Anthracnose stalk rot is characterized by a distinctive external blackening of the lower stalks resulting in large black streaks, while the pith turns dark brown and has a shredded appearance.
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