Ellagic Acid Potentiates the Inhibitory Effects of Fluconazole Against .

: Antifungal resistance to azoles, coupled with the increasing prevalence of infections, represents a significant public health challenge and has driven the search for new natural compounds that can act as alternatives or adjuvants to the current antifungals. Ellagic acid (EA) has demonstrated antifungal activity; however, its effects are not fully understood. In this study, we investigated the in vitro anti- activity of EA and its ability to potentiate the effects of fluconazole (FLZ) on : The Minimum Inhibitory Concentration (MIC) of EA was determined by broth microdilution and its interaction with FLZ was assessed using a checkerboard assay.

Changes in descending pain modulation during anti-TNF therapy. A prospective study in rheumatoid arthritis and spondyloarthritis.

Objective: In rheumatoid arthritis (RA) and spondyloarthritis (SpA), managing persistent pain remains challenging. Little is known regarding impaired pain pathways in these patients and the impact of bDMARDs. The objective of the RAPID (Rheumatism Pain Inhibitory Descending pathways) study was to assess pain thresholds and descending pain modulation in patients with active RA or SpA following introduction of a TNF inhibitor.

Growth and properties of hybrid Au-CoNinanowires embedded in SrTiO/SrTiO(001).

We present a sequential growth scheme based on pulsed laser deposition, which yields dense arrays of ultrathin, match-shaped Au/CoNi nanopillars, vertically embedded in SrTiOthin films. Analysis of the magnetic properties of these nanocomposites reveals a pronounced out-of-plane anisotropy. We show that the latter not only results from the peculiar nanoarchitecture of the hybrid films but is further enhanced by strong magneto-structural coupling of the wires to the surrounding matrix.

Development of molecular sterility assay for rapid quality release of cord blood erythrocytes units for transfusion.

Background: Umbilical cord blood (CB) units stored in banks are an important source of hematopoietic stem cells for transplantation and other cell therapies. New applications, such as their use in transfusions, require rapid quality release as cord blood red blood cells (CB-RBC) have a shorter shelf life.

Study Design And Methods: This project aims to investigate the most prevalent microbial contaminants in CB preparations and validate a rapid sterility testing strategy for CB-RBC based on an automated system (BACT/ALERT®) in tandem with a molecular assay (real-time PCR) capable of detecting at least 100 CFU/mL of Cutibacterium acnes in CB-RBC to accelerate the detection of the most common slow-growing bacteria.

The role of microRNAs in non-invasive diagnosis of bladder cancer: a systematic review.

Objective: MicroRNAs are small non-coding RNAs that are abundantly expressed in various biofluids, making them promising candidates for cancer biomarkers. This review aims to present current evidence on the use of miRNA as biomarkers for the non-invasive diagnosis of bladder cancer.

Methods: A systematic literature review, using the Medline database, was performed in July 2022 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.