Publications by authors named "F Rodriguez-Pacheco"
Article Synopsis
- - Inflammatory Bowel Diseases (IBD), like Crohn's disease, are chronic gut disorders influenced by genetic and environmental factors, including gene polymorphisms related to autophagy and non-steroidal anti-inflammatory drug (NSAID) usage.
- - NSAIDs can induce mitochondrial stress and mitophagy in intestinal cells, leading to the release of compounds that promote inflammation, particularly in the context of altered mitophagy seen in IBD patients.
- - Colonic organoids from Crohn's patients show an active mitochondrial Unfolded Protein Response (UPR) when treated with ibuprofen, suggesting that mitochondrial stress plays a significant role in IBD inflammation, especially in patients with varying disease activity.
infection (CDI) appears to be associated with different liver diseases. secretes membrane vesicles (MVs), which may be involved in the development of nonalcoholic fatty liver disease (NALFD) and drug-induced liver injury (DILI). In this study, we investigated the presence of -derived MVs in patients with and without CDI, and analyzed their effects on pathways related to NAFLD and DILI in HepG2 cells.
View Article and Find Full Text PDFThe composition and impact of fecal-microbe-derived extracellular vesicles (EVs) present in different diseases has not been analyzed. We determined the metagenomic profiling of feces and fecal-microbe-derived EVs from healthy subjects and patients with different diseases (diarrhea, morbid obesity and Crohn's disease (CD)) and the effect of these fecal EVs on the cellular permeability of Caco-2 cells. The control group presented higher proportions of and and lower proportions of , and in EVs when compared with the feces from which these EVs were isolated.
View Article and Find Full Text PDFThe effect of oleic acid (OA) on the regulation of the circadian rhythm present in human visceral (VAT) and subcutaneous (SAT) adipose tissue from patients with morbid obesity has not been analyzed yet. VAT and SAT explants from patients with morbid obesity were incubated with OA to analyze the circadian regulation of clock and other genes related to lipid metabolism (SREBP-1c, FAS, LPL and CPT1), and their association with baseline variables and the improvement of these patients after bariatric surgery. There were significant differences in amplitude and acrophase in VAT with respect to SAT.
View Article and Find Full Text PDFBackground: Little is known about the relation between morbid obesity and duodenal transcriptomic changes. We aimed to identify intestinal genes that may be associated with the development of obesity regardless of the degree of insulin resistance (IR) of patients.
Material And Methods: Duodenal samples were assessed by microarray in three groups of women: non-obese women and women with morbid obesity with low and high IR.