Publications by authors named "F Rodriguez Espinosa"
Article Synopsis
- - This article reviews innovative sustainable plant nutrition concepts, highlighting the impact of biostimulants on enhancing plant nutrition and their potential role in biofertilization.
- - It discusses the importance of micronutrients for plant health, strategies to improve plants' resilience to nutrient contaminants, and the benefits of biofortification for human health.
- - The article also covers emerging nanotechnology in fertilization, the relevance of circular economy principles for resource management, and concludes with a look at future challenges and opportunities in sustainable plant systems.
The mechanics of the extracellular matrix (ECM) determine cell activity and fate through mechanoresponsive proteins including Yes-associated protein 1 (YAP). Rigidity and viscous relaxation have emerged as the main mechanical properties of the ECM steering cell behavior. However, how cells integrate coexisting ECM rigidity and viscosity cues remains poorly understood, particularly in the high-stiffness regime.
View Article and Find Full Text PDFVirtual patients (VPs) are increasingly used in medical education to train clinical reasoning (CR) skills. However, optimal VP design for enhancing interactivity and authenticity remains unclear. Novel interactive modalities, such as large language model (LLM)-enhanced social robotic VPs might increase interactivity and authenticity in CR skill practice.
View Article and Find Full Text PDFLocalization optoacoustic tomography (LOT) has recently emerged as a transformative super-resolution technique breaking through the acoustic diffraction limit in deep-tissue optoacoustic (OA) imaging via individual localization and tracking of particles in the bloodstream. However, strong light absorption in red blood cells has previously restricted per-particle OA detection to relatively large microparticles, ≈5 µm in diameter. Herein, it is demonstrated that submicron-sized porous gold nanoparticles, ≈600 nm in diameter, can be individually detected for noninvasive super-resolution imaging with LOT.
View Article and Find Full Text PDFArticle Synopsis
- Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder linked to a mutation in the LMNA gene, leading to accelerated aging and early death from cardiovascular issues.
- Research using single-cell RNA sequencing on progerin-expressing mice revealed significant changes in endothelial cells, including alterations in gene expression, increased inflammation, and activation of a pathway (YAP/TAZ) related to mechanosensing.
- Targeting the YAP/TAZ pathway with a drug, verteporfin, reduced inflammation and atherosclerosis in the affected mice, suggesting potential new treatment options for HGPS-related vascular complications.