Publications by authors named "F Riviere"
N-myristoyltransferases (NMTs) catalyze essential acylations of N-terminal alpha or epsilon amino groups of glycines or lysines. Here, we reveal that peptides tightly fitting the optimal glycine recognition pattern of human NMTs are potent prodrugs relying on a single-turnover mechanism. Sequence scanning of the inhibitory potency of the series closely reflects NMT glycine substrate specificity rules, with the lead inhibitor blocking myristoylation by NMTs of various species.
View Article and Find Full Text PDFBackground: One of the major challenges in managing allergic bronchopulmonary aspergillosis remains consistent and reproducible assessment of response to treatment.
Research Question: What are the most relevant changes in CT scan parameters over time for assessing response to treatment?
Study Design And Methods: In this ancillary study of a randomized clinical trial (NebuLamB), patients with asthma with available CT scan and without exacerbation during a 4-month allergic bronchopulmonary aspergillosis exacerbation treatment period (corticosteroids and itraconazole) were included. Changed CT scan parameters were assessed by systematic analyses of CT scan findings at initiation and end of treatment.
Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort.
Eur Respir J
November 2023
Article Synopsis
- This global study investigates the long-term outcomes of patients with tuberculosis (TB) and COVID-19, highlighting a lack of prior longitudinal data on this combined condition.
- Data was collected from 788 patients across 31 countries from March 2020 to September 2022, showing a mortality rate of 10.8% during the study period.
- Key factors influencing mortality included older age, HIV infection, and the need for invasive ventilation, with patients suffering from both diseases experiencing significantly lower survival rates compared to those with only one of the diseases.
Introduction: Inflammatory lesions after Influenza A viruses (IAV) are potential therapeutic target for which better understanding of post-infection immune mechanisms is required. Most studies to evaluate innate immune reactions induced by IAV are based on quantitative/functional methods and anatomical exploration is most often non-existent. We aimed to study pulmonary damage and macrophage recruitment using two-photon excitation microscopy (TPEM) after IAV infection.
View Article and Find Full Text PDFArticle Synopsis
- N-myristoyltransferases (NMTs) are enzymes that convert myristoyl-CoA into myristoylated proteins, playing a critical role in guiding proteins to cell membranes.
- NMTs are part of the GCN5-related N-acetyltransferase family and are known for their ability to also interact with unusual substrates like lysine and acetyl-CoA.
- The chapter discusses the kinetic methods used to study and understand the specific catalytic activities of NMTs in laboratory settings.