Can immunohistochemistry improve the pathological diagnosis of placenta accreta spectrum (PAS) disorders?

Purpose: The term of placenta accreta spectrum (PAS) disorder includes all grades of abnormal placentation. It is crucial for pathologist provide standardized diagnostic assessment to evaluate the outcome of management strategies. Moreover, a correct and safe diagnosis is useful in the medico-legal field when it becomes difficult for the gynecologist to demonstrate the suitability and legitimacy of demolitive treatment.

Human Pulmonary Dirofilariasis Due to : The First Italian Case Confirmed by Polymerase Chain Reaction Analysis, with a Systematic Literature Review.

Dirofilariasis is a zoonosis caused by nematodes of the genus is cosmopolitan as regards its distribution in animals, being responsible for human pulmonary dirofilariasis in the New World. However, human infections by are exceptional in Europe, and the previously reported Italian cases of pulmonary dirofilariasis were due to . We performed a systematic literature review of the Italian cases of human dirofilariasis due to according to the PRISMA guidelines.

Promoter methylation and downregulated expression of the gene in ovarian carcinoma.

is a gene involved in the development of mesodermal derivatives. As the ovaries and the female reproductive system are of mesodermal origin, the aim of the present study was to determine the methylation status of the gene promoter and the expression levels of in ovarian carcinoma, which is the most lethal and aggressive type of gynecological tumor, in order to determine the role of in the pathogenesis of ovarian carcinoma. This alteration could be used to predict tumor development, progression, recurrence and therapeutic effects.

Tungiasis in Italy: An imported case of Tunga penetrans and review of the literature.

Tungiasis is an animal and human parasitic disease caused by fleas of the genus Tunga (Siphonaptera, Tungidae), endemic in equatorial and subtropical regions and rarely described in European countries, where clinicians and general pathologists could be not aware of this parasitic disease. To our knowledge, only 75 cases of human tungiasis (not all described in detail) were previously reported in Italy. We described a new case in a 34-year-old Italian flight attendant who developed a granuloma-like, ulcerated nodule in the subungual region of his left 5th toe, partially detaching the nail, about 20-30 days after his return from Brazil.